book offers detailed and up-to-date information about the role, the causes, the
symptoms, the progression and the treatment of inflammation processes in heart
failure, given by a combination of experts in the field that provide accurate
and comprehensive overviews of their research areas.
The book is
divided in 3 sections and 14 chapters, all adequately introduced and
Section 1 provides
a thorough overview of the role of inflammation in heart failure. Interestingly,
the authors highlight the need of better understanding the different causes and
the different local/systemic pathophysiological processes that lead to this
syndrome, in order to identify specific treatments. Of note, the last chapter
of the section is focused on the description and analysis of different animal
models of heart failure.
is focused on inflammatory mediators as biomarkers of heart failure. After an
in-depth review and classification of these biomarkers (Chapter 7), the book
presents a very interesting technical chapter that describes the analytical
techniques currently available for their measurement, and finally discusses the
potential of imaging techniques as powerful diagnostic tools, well-identifying
the most promising molecular imaging targets.
Section 3, different possible clinical strategies to
target inflammatory response, to control it, and exploit it, for therapeutic
purposes, are discussed, with particular attention to clinical evidences,
clinical trials, and future perspectives.
book is mainly addressed to a readership of researchers in the cardiovascular
field and cardiologists, with a strong biology and physiology background. The
addition of some more schematic and intuitive representations/diagrams of the
complex pathophysiological pathways and processes might have been useful for a
broader audience of readers. The book could be of interest for researchers in
the field of cardiovascular biomaterials who want to thoroughly understand the
process of inflammation, also occurring upon implantation of
biomaterials/devices, and the possible strategies to monitor, control, and